Originally published in 2015 as an answer on Quora.
I'm red-green color blind and I work as a Product Designer at Quora. My color blindness is on the stronger side (~1% of all men instead of a more common kind that affects about 5%).
My tl;dr for this is that in the grand scheme of things, making a color choice between a green and brown is the kind of decision we make rarely enough that you can ask for help and it really isn't a big deal.
Make no mistake, it is a handicap, but for me a minor one. I do wonder what it's like to be, for example, a fashion designer or interior designer, where you're making a lot more color decisions. I'd imagine it would be harder.
When people first find out, I often get a "You're a colorblind designer, WHAT?!" reaction. My usual response is two part:
Overall, I feel like the handicap makes me a better product designer (emphasis on product because I'm not sure it would make me a better fashion or interior designer), for the following two reasons:
On that note, I'd like to add that designing for color blind people is not that hard -- tools like ColorSchemeDesigner have a color blind friendly mode that simply won't let you pick a palette that's inaccessible. I really recommend using these on any product.
Color blindness is a huge consideration when building a safety-related product. You really don't want to use the wrong red and green on a stop/go sign for example (for the record, traffic lights are very, very easy to distinguish between).
That's really the gist of it. To answer the last point, yeah, I've generally made it pretty clear upfront when looking for jobs that I'm color blind, and most good employers start out asking if it has affected my work in the past.
An immediately negative reaction is usually a sign of incomplete understanding of how color blindness works.
I'm really curious to hear if there's color blind designers in fashion, interior or graphic design and how this affects their work.